The responsible party is the part of the application people get wrong. The instructions to Form SS-4 are explicit: "Unless the applicant is a government entity, the responsible party must be an individual (that is, a natural person), not an entity," and only a government entity may enter an EIN in that field. So a holding company cannot be named as the responsible party for a subsidiary, and a promoter or filing service cannot stand in for the owner. The role has to be a natural person who actually controls or directs the entity and its funds. Where that person has no Social Security number or ITIN and is ineligible to obtain one, the instructions direct the applicant to enter "foreign" rather than to name somebody else, which is the point foreign-owned entities most often get wrong.
That designation is not a one-time entry on a form. The instructions to Form 8822-B state that "any entity with an EIN is required to report a change in its 'responsible party' ... within 60 days of the change," citing Treasury Regulation section 301.6109-1(d)(2)(ii), and add that entities changing their address or their responsible party must file the form "whether or not they are engaged in a trade or business." The reach of that last clause is easy to underestimate. A family trust whose trustee changes, an estate whose personal representative is replaced, and a two-member LLC one member leaves are all entities with EINs and all inside the rule, none of which thinks of itself as a business with an IRS reporting deadline. What happens on a missed deadline is worth knowing too, because it is not a penalty. The form itself states that filing is mandatory once the responsible party has changed and that no penalty applies for failing to file it, but that an entity which has not told the IRS who controls it may not receive a notice of deficiency or a demand for tax, while penalties and interest on the underlying liability accrue regardless. The exposure is a missed notice rather than a fine.
Sequence matters too, and the IRS is explicit about it. For a legal entity, "form your entity through your state before you apply for an EIN," because an application filed ahead of the state formation may be delayed. Applying first is a common and avoidable false start.
The other half of the page is what an EIN does not do. It is not a business license, and a local or occupational license is a separate filing. It is not a state tax registration, and a state identification number for withholding or sales tax is issued by the state, not the IRS. It is not a seller's permit, and it is not a DUNS number, which is a commercial credit identifier from a private company. Readers regularly arrive with all four collapsed into one idea, and only the EIN is federal. It is also not liability protection. That comes from the entity, if the entity is respected, and even then insurance and entity choice answer different problems.