The Centers for Medicare & Medicaid Services is the agency of the U.S. Department of Health and Human Services responsible for the federal government's major health coverage programs. In its own description, "CMS is the federal agency that provides health coverage to more than 160 million through Medicare, Medicaid, the Children's Health Insurance Program, and the Health Insurance Marketplace." The agency writes the regulations for those programs, pays or oversees the payment of claims, and publishes the consumer sites Medicare.gov and HealthCare.gov.
The name is spelled with an ampersand on the agency's own materials and is also written with "and"; both refer to the same agency. It should not be confused with the Social Security Administration, which is a separate, independent agency even though it handles much of Medicare enrollment.